The synthesis of the evidence should reflect the a priori plan in the protocol for incorporating risk of bias of individual studies in qualitative or quantitative analyses.
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EPCs should report the outcomes of all preplanned analyses that included risk-of-bias criteria regardless of statistical significance or the direction of the effect. Published reviews should also include justifications of all post hoc decisions to limit synthesis of included studies to a subset with common methodological or reporting attributes.
When reviewers exclude high risk-of-bias studies from their analysis entirely without any sensitivity analyses, we recommend that reviewers explain their decision.
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Identifying, Selecting, and Assessing Categories of Risk of Bias Identifying Categories of Risk of Bias Different categories of bias are often described by a host of different terms and the same terms are sometimes used to refer to different categories of bias depending on the study design of interest.
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